Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.

K. Kitano, S. Sakata, S. Kohgo, M. Matsuoka, E. Kodama, H. Mitsuya, H. Ohrui

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.

Original languageEnglish
Pages (from-to)105-106
Number of pages2
JournalNucleic acids symposium series
Issue number44
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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