Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.

K. Kitano; S. Sakata; S. Kohgo; M. Matsuoka; E. Kodama; H. Mitsuya; H. Ohrui

doi:10.1093/nass/44.1.105

Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.

K. Kitano, S. Sakata, S. Kohgo, M. Matsuoka, E. Kodama, H. Mitsuya, H. Ohrui

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.

Original language	English
Pages (from-to)	105-106
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	44
DOIs	https://doi.org/10.1093/nass/44.1.105
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/nass/44.1.105

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abstract = "Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.",

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AU - Kitano, K.

AU - Sakata, S.

AU - Kohgo, S.

AU - Matsuoka, M.

AU - Kodama, E.

AU - Mitsuya, H.

AU - Ohrui, H.

PY - 2000

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AB - Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.

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Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.

Abstract

ASJC Scopus subject areas

UN SDGs

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