Synthesis of 4′-C-ethynyl and 4′-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity

Satoru Kohgo, Kohei Yamada, Kenji Kitano, Shinji Sakata, Hiroyuki Hayakawa, Daisuke Nameki, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya, Hiroshi Ohrui

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purine 2′-deoxynucleosides bearing an ethynyl or a cyano group at C-4′ of the sugar moiety were synthesized from the corresponding 2′-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.

Original languageEnglish
Pages (from-to)887-889
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
Publication statusPublished - 2003 Sep 29
Externally publishedYes

Keywords

  • 4′-C-Substituted nucleosides
  • Anti-HIV activitiy
  • Drug-resistant HIV

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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    Kohgo, S., Yamada, K., Kitano, K., Sakata, S., Hayakawa, H., Nameki, D., Kodama, E., Matsuoka, M., Mitsuya, H., & Ohrui, H. (2003). Synthesis of 4′-C-ethynyl and 4′-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity. Nucleosides, Nucleotides and Nucleic Acids, 22(5-8), 887-889. https://doi.org/10.1081/NCN-120022678