Synthesis of 4′-C-ethynyl and 4′-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity

Satoru Kohgo, Kohei Yamada, Kenji Kitano, Shinji Sakata, Hiroyuki Hayakawa, Daisuke Nameki, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya, Hiroshi Ohrui

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Purine 2′-deoxynucleosides bearing an ethynyl or a cyano group at C-4′ of the sugar moiety were synthesized from the corresponding 2′-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.

Original languageEnglish
Pages (from-to)887-889
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • 4′-C-Substituted nucleosides
  • Anti-HIV activitiy
  • Drug-resistant HIV

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

Fingerprint

Dive into the research topics of 'Synthesis of 4′-C-ethynyl and 4′-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity'. Together they form a unique fingerprint.

Cite this