Abstract
N-Alkoxycarbonylation reactions of dihydropyrimidines with trichloromethyl chloroformate (phosgene dimer) and an alcohol were carried out in order to obtain the dihydropyrimidines with a complicated alkyl group or an alkyl group containing a nitrogen atom. Especially, the synthetically difficult problem of the unstable N-substituted dihydropyrimidines containing a nitrogen atom in an ester group was overcome by the method II: 0.5-1.2 mol equiv. of phosgene dimer, 1.0-6.0 equiv. of tertiary aminoalcohol, and 6 equiv. of Et3N in THF at -23 °C-r.t.
Original language | English |
---|---|
Pages (from-to) | 769-774 |
Number of pages | 6 |
Journal | Heterocycles |
Volume | 27 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1988 Mar 1 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry