Synthesis of 3-methylenepyrrolidines by palladium-catalyzed [3+2] cycloaddition of alkylidene-cyclopropanes with imines

Byoung Ho Oh, Itaru Nakamura, Shinichi Saito, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh3)4 and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products, pyrrolidine derivatives, in good to excellent yields.

Original languageEnglish
Pages (from-to)247-257
Number of pages11
JournalHeterocycles
Volume61
DOIs
Publication statusPublished - 2003 Dec 31

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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