Synthesis of 3-methylenepyrrolidines by palladium-catalyzed [3+2] cycloaddition of alkylidene-cyclopropanes with imines

Byoung Ho Oh; Itaru Nakamura; Shinichi Saito; Yoshinori Yamamoto

doi:10.3987/com-03-s30

Synthesis of 3-methylenepyrrolidines by palladium-catalyzed [3+2] cycloaddition of alkylidene-cyclopropanes with imines

Byoung Ho Oh, Itaru Nakamura, Shinichi Saito, Yoshinori Yamamoto

SCI - Research and Analytical Center for Giant Molecules

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh₃)₄ and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products, pyrrolidine derivatives, in good to excellent yields.

Original language	English
Pages (from-to)	247-257
Number of pages	11
Journal	Heterocycles
Volume	61
DOIs	https://doi.org/10.3987/com-03-s30
Publication status	Published - 2003 Dec 31

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Synthesis of 3-methylenepyrrolidines by palladium-catalyzed [3+2] cycloaddition of alkylidene-cyclopropanes with imines",

abstract = "Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh3)4 and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products, pyrrolidine derivatives, in good to excellent yields.",

author = "Oh, {Byoung Ho} and Itaru Nakamura and Shinichi Saito and Yoshinori Yamamoto",

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AU - Oh, Byoung Ho

AU - Nakamura, Itaru

AU - Saito, Shinichi

AU - Yamamoto, Yoshinori

PY - 2003/12/31

Y1 - 2003/12/31

N2 - Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh3)4 and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products, pyrrolidine derivatives, in good to excellent yields.

AB - Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh3)4 and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products, pyrrolidine derivatives, in good to excellent yields.

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DO - 10.3987/com-03-s30

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JF - Heterocycles

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