Abstract
3-[1H-Imidazol-4-yl]propyl 4-fluorobenzyl ether (fluoroproxyfan), a potential histamine H3 receptor ligand, was labeled with 18F for clinical PET studies. The synthesis involved the O-alkylation of 3-(1 -triphenylmethyl-1H-imidazol-4-yl)propanol with 4-[18F]fluorobenzyl bromide in the presence of silver triflate and a non-nucleophilic amine base. 4-[18F]Fluoroproxyfan was obtained within 100 min from the end of bombardment (EOB) in 10% radiochemical yield (decay corrected to EOB) with a radiochemical purity > 99% and a specific activity >150 GBq/μmol.
Original language | English |
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Pages (from-to) | 873-882 |
Number of pages | 10 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 43 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Fluorine-18
- Fluoroproxyfan
- Histamine H receptor
- PET
- Radioligand
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry