Abstract
(1R,4S,5R)-9(4,5-Bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine [(-)-BCA] has been synthesized from (-)-Corey lactone in 11 steps and shown to have potent and selective effects against human immmunodeficiency virus type 1. The result demonstrated that the potent-HIV activity of racemic BCA obtained in our previous work is expressed solely by the (1R,4S,5R)-(-)-isomer.
Original language | English |
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Pages (from-to) | 3507-3510 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 33 |
Issue number | 24 |
DOIs | |
Publication status | Published - 1992 Jun 9 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry