@article{b796bc8958cf4d45a3907c75a416f0d3,
title = "Synthesis of 1,6-dihydropyrimidines via copper-catalyzed multistep cascade reactions between O-propargylic aldoximes and isocyanates",
abstract = "Multi-step cascade reactions of O-propargylic oximes with isocyanates were carried out in the presence of copper catalysts to afford the corresponding 1,6-dihydropyrimidines in good yields. The multi-step reactions consisted of a 2,3-rearrangement, a [3+2] cycloaddition, decarboxylative ring opening involving a 1,4-hydrogen shift, and a 6π-electrocyclization.",
keywords = "Alkyne, Cascade reaction, Copper-catalyzed, Oximes, Rearrangement",
author = "Itaru Nakamura and Toshiki Onuma and Dong Zhang and Masahiro Terada",
note = "Funding Information: We thank Prof. Takeaki Iwamoto and Prof. Shintaro Ishida (Tohoku University, Japan) for X-ray crystallographic expertise. This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}Molecular Activation Directed toward Straightforward Synthesis{\textquoteright} from the Ministry of Education, Culture, Sports, Science and Technology, Japan. ",
year = "2014",
month = feb,
day = "5",
doi = "10.1016/j.tetlet.2013.12.105",
language = "English",
volume = "55",
pages = "1178--1182",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "6",
}