Abstract
Multi-step cascade reactions of O-propargylic oximes with isocyanates were carried out in the presence of copper catalysts to afford the corresponding 1,6-dihydropyrimidines in good yields. The multi-step reactions consisted of a 2,3-rearrangement, a [3+2] cycloaddition, decarboxylative ring opening involving a 1,4-hydrogen shift, and a 6π-electrocyclization.
Original language | English |
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Pages (from-to) | 1178-1182 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2014 Feb 5 |
Keywords
- Alkyne
- Cascade reaction
- Copper-catalyzed
- Oximes
- Rearrangement
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry