Synthesis of 1-11C-labeled fatty acid from [11C]HCN

Toshihiro Takahashi, Tatsuo Ido, Kentaro Hatano, Ren Iwata, Hiroaki Nakanishi

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9 Citations (Scopus)

Abstract

A new chemical approach to the preparation of [1-11C]fatty acids from [11C]HCN has been developed. Four straight chain [1-11C]fatty acids (C15C18) and one branched chain [1-11C]fatty acid (3-methylheptadecanoic acid) were produced by the reaction of alkyl bromides with 11CN- and subsequent hydrolysis. The synthesis time was 47-67 min after the end of bombardment, with radiochemical yields of 16-20 mCi (70-83%) for a series of straight chain [1-11C]fatty acids and 4-8 mCi (33-42%) for 3-methyl [1-11C]heptadecanoic acid (from 120 mCi of trapped [11C]HCN). This method has some advantages, such as no requirement of absolutely anhydrous solvent, easy 11C-labeling using an extremely small amount of substrate, and good reproducibility.

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume41
Issue number7
DOIs
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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