Synthesis of 1-O-(8-[18F]fluorooctanoyl)-2-O-palmitoyl-rac-glycerol for imaging intracellular signal transduction

Shozo Furumoto, Ren Iwata, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

An improved approach to the synthesis of 1-O-(8-[18F]fluorooctanoyl)-2-O-palmitoyl-rac-glycerol (rac-1,2-[18F]FDAG) has been developed. We designed and synthesized two new types of precursors for the radiosynthesis and investigated their general utility. Each precursor was smoothly radiofluorinated (5 min) and the protecting group at the 3-O-position was rapidly removed (1 min). The resulting rac-1,2-[18F]FDAG was obtained in overall radiochemical yields of 20-30% (EOB) within 70 min including final preparative HPLC separation.

Original languageEnglish
Pages (from-to)1159-1172
Number of pages14
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume43
Issue number12
DOIs
Publication statusPublished - 2000 Nov 18

Keywords

  • Diacylglycerols
  • Fluorine-18
  • Intracellular signal transduction
  • Second messenger

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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