Abstract
An improved approach to the synthesis of 1-O-(8-[18F]fluorooctanoyl)-2-O-palmitoyl-rac-glycerol (rac-1,2-[18F]FDAG) has been developed. We designed and synthesized two new types of precursors for the radiosynthesis and investigated their general utility. Each precursor was smoothly radiofluorinated (5 min) and the protecting group at the 3-O-position was rapidly removed (1 min). The resulting rac-1,2-[18F]FDAG was obtained in overall radiochemical yields of 20-30% (EOB) within 70 min including final preparative HPLC separation.
Original language | English |
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Pages (from-to) | 1159-1172 |
Number of pages | 14 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 43 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2000 Nov 18 |
Keywords
- Diacylglycerols
- Fluorine-18
- Intracellular signal transduction
- Second messenger
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry