Synthesis of 1-[2-[18F]Fluoro-1-(hydroxymethyl)-ethoxy]methyl-2-nitroimidazole ([18F]FENI), a potential agent for imaging hypoxic tissues by PET

Hiroaki Wada, Ren Iwata, Tatsuo Ido, Yoshihiro Takai

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Fluorine-18 labeled 1-[2-fluoro-1-(hydroxymethyl)ethoxy]-mehyl-2-nitroimidazole ([18F]FENI), a novel, potential radiotracer for imaging hypoxic tissue by PET, was synthesized. The [18F]FENI was prepared by nucleophilic 18F-fluorination of the precursor, 1-[2-(toluene-4-sulfoxy)-1-(acetoxymethyl)ethoxy]methyl-2-nitroimidazole, followed by deprotection and HPLC purification. Radiochemically pure [18F]FENI was obtained in overall yields of 3-11% (EOB) with specific activity of > 26 GBq/μmol (EOS) within 90 min.

    Original languageEnglish
    Pages (from-to)785-793
    Number of pages9
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume43
    Issue number8
    DOIs
    Publication statusPublished - 2000

    Keywords

    • 1-[2-fluoro-1-(hydroxymethyl)ethoxyl]
    • FENI
    • Fluorine-18
    • Hypoxic cell marker
    • PET
    • Tumor imaging

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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