Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives

Fumi Nagatsugi, Shigeki Sasaki, Minoru Maeda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis. The synthetic procedures offer easy and convenient access to the corresponding 18F-labeled analogs using the readily available [18F]fluoride ion.

Original languageEnglish
Pages (from-to)373-383
Number of pages11
JournalJournal of Fluorine Chemistry
Volume56
Issue number3
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives'. Together they form a unique fingerprint.

  • Cite this