Isoquinoline-type carbolines i.e. β-, and γ-carbolines and their N- oxides were synthesized from 2(or 3)ethynylindole-3(or 2)-carbaldehydes, which were synthesized by electrophilic substitution with dichloromethyl methyl ether in the presence of titanium tetrachloride, or by lithiation with tert-butyllithium, followed by formylation with methyl formate.
- Palladium- catalyzed reaction
ASJC Scopus subject areas
- Drug Discovery