Synthesis of β- and γ-carbolines and their N-oxides from 2(or 3)- ethynylindole-3(or 2)-carbaldehydes

Takao Sakamoto, Atsushi Numata, Hironori Saitoh, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Isoquinoline-type carbolines i.e. β-, and γ-carbolines and their N- oxides were synthesized from 2(or 3)ethynylindole-3(or 2)-carbaldehydes, which were synthesized by electrophilic substitution with dichloromethyl methyl ether in the presence of titanium tetrachloride, or by lithiation with tert-butyllithium, followed by formylation with methyl formate.

Original languageEnglish
Pages (from-to)1740-1743
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume47
Issue number12
DOIs
Publication statusPublished - 1999 Dec

Keywords

  • Carboline
  • Cyclization
  • Ethynylindolecarbaldehyde
  • N-oxide
  • Ortho-lithiation
  • Palladium- catalyzed reaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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