Synthesis, characterization and photodynamic therapy properties of an octa-4-tert-butylphenoxy-substituted phosphorus(V) triazatetrabenzcorrole

Maohu Shi, Jiangwei Tian, Colin Mkhize, Gugu Kubheka, Jinfeng Zhou, John Mack, Tebello Nyokong, Zhen Shen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A novel octa-4-tert-butylphenoxy-substituted phosphorus(V) triazatetrabenzcorrole (PVTBC), has been synthesized and characterized by MALDI-TOF MS and NMR, FT-IR and MCD spectroscopy. The fluorescence emission spectrum was used to determine the fluorescence quantum yield and the quantum yield for singlet oxygen generation was calculated by using 1,3-diphenylisobenzofuran as a scavenger. The photocytoxicity against U87MG cells was measured. The results indicated that PVTBC is potentially useful as an NIR region photosensitizer for photodynamic therapy (PDT).

Original languageEnglish
Pages (from-to)698-707
Number of pages10
JournalJournal of Porphyrins and Phthalocyanines
Volume18
DOIs
Publication statusPublished - 2014 Aug

Keywords

  • MCD spectroscopy
  • Photocytoxicity
  • TD-DFT calculations
  • Triazatetrabenzcorrole

ASJC Scopus subject areas

  • Chemistry(all)

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