Abstract
Deoxyribonucleoside analogues bearing acetylene group at the pseudo-5′-position and azido group at the pseudo-3′-position have been synthesized by transglycosylation reaction of deoxythymidine analogue with adenine, cytosine, and guanine nucleobases as nucleophiles. The structures of analogues were studied in crystalline state by X-ray crystallography as well as in solution phase by NMR spectroscopy and showed the puckering conformations similar to the natural congeners.
Original language | English |
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Pages (from-to) | 2036-2038 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2010 Apr 14 |
Keywords
- Artificial deoxyribonucleoside
- Puckering conformation
- Transglycosylation
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry