Synthesis and structure revision of litseaone A

Hideaki Kageji, Naoki Mori, Hirosato Takikawa, Hidenori Watanabe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Litseaone A, isolated from the stem barks of Litsea rubescens and Litsea pedunculata, is a chalcone derivative with a novel spiro-epoxide moiety. The structural revision of litseaone A was achieved by the racemic synthesis of the proposed structure and the asymmetric synthesis of the revised structure. The major tautomeric structure of litseaone A and the relative stereochemistry at the epoxide carbon center were also clarified.

Original languageEnglish
Pages (from-to)7074-7081
Number of pages8
JournalTetrahedron
Volume74
Issue number49
DOIs
Publication statusPublished - 2018 Dec 6
Externally publishedYes

Keywords

  • Litseaone A
  • Spiro-epoxide
  • Structure revision
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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