Synthesis and structure characterization of sulfur ethers containing 1,2,4-triazoie and 1,3,4-oxadiazole

Compound 3 was prepared by reaction of benzohydrazide (2) with CS ₂ in the presence of KOH as solvent. This compound converted to (4-amino-5-phenyl-4H-1,2,4-triazol-3-ylsulfanyl)-acetic acid hydrazide (6) by the reactions of cyclization, substitution and hydrazinolysis in the presence of hydrazine hydrate. Then 5-(4-amino-5-phenyl-4H-1,2,4-triazol-3- ylsulfanylmethyl)-1,3,4-oxadiazole-2-thiol (7) were obtained by a refluence of compound 6 with CS₂. This intermediate reacted with several substituted-benzyl chloride to afford a series of new derivatives A1∼A6; in the meantime, reacted with several substituted-benzaldehyde to afford a series of new derivatives B1∼B15. The structures of new products were characterized by means of ¹H NMR, ¹³C NMR, IR, MS or HRMS techniques.