Synthesis and solution properties of hydrophobically modified cluster dextrin

Yavoi Ozawa, Nobuyuki Morimoto, Shin Ichi Kitamura, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review

Abstract

We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5 by 1H-NMR. Solution properties of CH-CDex in water were investigated by SEC-MALS and DLS. CH-CDex formed self-associates consisting of 3-4 CH-CDex macromolecules, and the particle size (diameter) was 40 nm by DLS.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Cluster dextrin /
  • Hydrophobically modified polysaccharides
  • Nanogels
  • Self-assembly

ASJC Scopus subject areas

  • Engineering(all)

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