An open-chain carboxylic acid host with a chiral sulfinyl group (4) was synthesized from 3,3¤-thiobis[(5-tert-butyl-2-hydroxyphenyl)acetic acid] (2) by oxidation of the epithio linkage with mCPBA, followed by acid-catalyzed monoesterification with propan-1-ol. The monoester was resolved via diastereomeric salt formation using quinidine as a resolving agent. The absolute configuration of (+)-4 was assigned to be (R) by X-ray analysis.
|Number of pages||3|
|Journal||Bulletin of the Chemical Society of Japan|
|Publication status||Published - 2022|
- Chiral host
- Nanoporous molecular crystal
- Optical resolution
ASJC Scopus subject areas