Synthesis and properties of oligo-omega-amino acids derivatives containing nucleosides.

T. Wada, N. Minamimoto, K. Okada, K. Miyabayashi, Y. Inaki, M. Miyata

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Abstract

Nucleic acid analogs, that consist of oligo-omega-amino acids as main chains were synthesized. At first, hydroxyl group of deoxy and ribonucleic acid was converted into amino or carboxylic acid group. Then, amino acid derivatives containing aminonucleoside or nucleoside-5'-carboxylic acid at alpha-position were synthesized. Amino acids used in this paper were L-glutamic acid, L-2-amino adipic acid (L-homo glutamic acid), L-ornithine, and L-lysine. These amino acid derivatives containing nucleoside were oligomerized by activated ester methods and Merrifield's solid phase synthesis. The properties of these analogs were studied and compared with oligo-alpha-amino acid derivatives containing nucleoside at omega-position.

Original languageEnglish
Pages (from-to)189-190
Number of pages2
JournalNucleic acids symposium series
Issue number34
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Medicine(all)

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    Wada, T., Minamimoto, N., Okada, K., Miyabayashi, K., Inaki, Y., & Miyata, M. (1995). Synthesis and properties of oligo-omega-amino acids derivatives containing nucleosides. Nucleic acids symposium series, (34), 189-190.