Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Hidehito Fujisawa, Tomoya Fujiwara, Yoshio Takeuchi, Kenji Omata

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.

Original languageEnglish
Pages (from-to)524-528
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number5
DOIs
Publication statusPublished - 2005 May

Keywords

  • 2-aryl-2-fluoropropionic acid
  • Isostere
  • Non-steroidal anti-inflammatory drug
  • Perchloryl fluoride
  • α-fluorination

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)'. Together they form a unique fingerprint.

Cite this