Synthesis and Interaction Studies on Water Soluble Nucleic Acid Analogs: Poly(L-lysine) Derivatives Containing Thymine and Hypoxanthine*

Takehiko Wada; Yoshiaki Inaki; Kiichi Takemoto

doi:10.1177/088391159200700104

Synthesis and Interaction Studies on Water Soluble Nucleic Acid Analogs: Poly(L-lysine) Derivatives Containing Thymine and Hypoxanthine*

Takehiko Wada, Yoshiaki Inaki, Kiichi Takemoto

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Nucleic acid analogs were prepared by grafting nucleic acid base derivatives containing hydroxy groups onto poly(L-lysine). The polymers con tained about 70 unit% of the nucleic acid bases, and were easily soluble in water at neutral pH value. Conformational changes and polymer complexes with polynucleotides [Poly(A) and Poly(C)] were observed with specific base- base interactions in aqueous solution.

Original language	English
Pages (from-to)	25-38
Number of pages	14
Journal	Journal of Bioactive and Compatible Polymers
Volume	7
Issue number	1
DOIs	https://doi.org/10.1177/088391159200700104
Publication status	Published - 1992 Jan
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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abstract = "Nucleic acid analogs were prepared by grafting nucleic acid base derivatives containing hydroxy groups onto poly(L-lysine). The polymers con tained about 70 unit% of the nucleic acid bases, and were easily soluble in water at neutral pH value. Conformational changes and polymer complexes with polynucleotides [Poly(A) and Poly(C)] were observed with specific base- base interactions in aqueous solution.",

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