Synthesis and Interaction Studies on Water Soluble Nucleic Acid Analogs: Poly(L-lysine) Derivatives Containing Thymine and Hypoxanthine*

Takehiko Wada, Yoshiaki Inaki, Kiichi Takemoto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Nucleic acid analogs were prepared by grafting nucleic acid base derivatives containing hydroxy groups onto poly(L-lysine). The polymers con tained about 70 unit% of the nucleic acid bases, and were easily soluble in water at neutral pH value. Conformational changes and polymer complexes with polynucleotides [Poly(A) and Poly(C)] were observed with specific base- base interactions in aqueous solution.

Original languageEnglish
Pages (from-to)25-38
Number of pages14
JournalJournal of Bioactive and Compatible Polymers
Volume7
Issue number1
DOIs
Publication statusPublished - 1992 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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