Synthesis and interaction studies of oligo and polyamino acids derivatives containing nucleosides.

T. Wada, E. Mochizuki, Y. Inaki, K. Takemoto

Research output: Contribution to journalArticle

Abstract

Nucleic acid analogs of L-lysine derivatives containing uridine and/or adenosine were synthesized. As dimer models, Lys(Urd)-Lys(Urd) and Lys(Urd)-Lys(Ado) were prepared by activated ester method. These dimers were found to form complex with Poly A, which was observed from hypochromicity of UV spectra. Furthermore poly-L-lysine derivative containing uridine was also prepared. The maximum hypochromicity value of this polymer model with PolyA was higher than that of dimer models.

Original languageEnglish
Pages (from-to)19-20
Number of pages2
JournalNucleic acids symposium series
Issue number25
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Medicine(all)

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