Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

Shigeki Tsuchiya; Yuko Cho; Keiichi Konoki; Kazuo Nagasawa; Yasukatsu Oshima; Mari Yotsu-Yamashita

doi:10.1039/c4ob00071d

Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Here, we describe the synthesis of the genetically predicted biosynthetic intermediates of the neurotoxin saxitoxin (STX) (1), 2, 6 and 7, and identification of 2 and 6 in toxin-producing microorganisms. This is the first chemical evidence supporting the genetically predicted biosynthetic route toward 1.

Original language	English
Pages (from-to)	3016-3020
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	19
DOIs	https://doi.org/10.1039/c4ob00071d
Publication status	Published - 2014 May 21

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c4ob00071d

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Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2). / Tsuchiya, Shigeki; Cho, Yuko ; Konoki, Keiichi et al.

In: Organic and Biomolecular Chemistry, Vol. 12, No. 19, 21.05.2014, p. 3016-3020.

Research output: Contribution to journal › Article › peer-review

Tsuchiya, S, Cho, Y , Konoki, K, Nagasawa, K, Oshima, Y & Yotsu-Yamashita, M 2014, 'Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)', Organic and Biomolecular Chemistry, vol. 12, no. 19, pp. 3016-3020. https://doi.org/10.1039/c4ob00071d

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Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

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