Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Takashi Takahashi, Kazuoki Nakai, Takayuki Doi, Masa Yasunaga, Hiroshi Nakagawa, Toshihisa Ishikawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.

Original languageEnglish
Pages (from-to)2601-2605
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number10
DOIs
Publication statusPublished - 2005 May 16
Externally publishedYes

Keywords

  • Multidrug resistance reversal agents

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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