Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Takashi Takahashi; Kazuoki Nakai; Takayuki Doi; Masa Yasunaga; Hiroshi Nakagawa; Toshihisa Ishikawa

doi:10.1016/j.bmcl.2005.03.038

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Takashi Takahashi, Kazuoki Nakai, Takayuki Doi, Masa Yasunaga, Hiroshi Nakagawa, Toshihisa Ishikawa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.

Original language	English
Pages (from-to)	2601-2605
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2005.03.038
Publication status	Published - 2005 May 16
Externally published	Yes

Keywords

Multidrug resistance reversal agents

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer. / Takahashi, Takashi; Nakai, Kazuoki; Doi, Takayuki; Yasunaga, Masa; Nakagawa, Hiroshi; Ishikawa, Toshihisa.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 10, 16.05.2005, p. 2601-2605.

Research output: Contribution to journal › Article › peer-review

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AU - Ishikawa, Toshihisa

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