Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Takashi Takahashi; Kazuoki Nakai; Takayuki Doi; Masa Yasunaga; Hiroshi Nakagawa; Toshihisa Ishikawa

doi:10.1016/j.bmcl.2005.03.038

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Takashi Takahashi, Kazuoki Nakai, Takayuki Doi, Masa Yasunaga, Hiroshi Nakagawa, Toshihisa Ishikawa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.

Original language	English
Pages (from-to)	2601-2605
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2005.03.038
Publication status	Published - 2005 May 16
Externally published	Yes

Keywords

Multidrug resistance reversal agents

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2005.03.038

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Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer. / Takahashi, Takashi; Nakai, Kazuoki; Doi, Takayuki; Yasunaga, Masa; Nakagawa, Hiroshi; Ishikawa, Toshihisa.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 10, 16.05.2005, p. 2601-2605.

Research output: Contribution to journal › Article › peer-review

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abstract = "We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.",

keywords = "Multidrug resistance reversal agents",

author = "Takashi Takahashi and Kazuoki Nakai and Takayuki Doi and Masa Yasunaga and Hiroshi Nakagawa and Toshihisa Ishikawa",

note = "Funding Information: The authors cordially thank Prof. Kazumitsu Ueda (Kyoto Univ.) for generously providing us with MDR KB-G2 and parental KB-3-1 cells. This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (No. 14103013 to T.T.) as well as a research grant (No. 13NP0401 to T.I.) for Creative Scientific Research from the Japan Society for the Promotion of Science.",

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AU - Nakai, Kazuoki

AU - Doi, Takayuki

AU - Yasunaga, Masa

AU - Nakagawa, Hiroshi

AU - Ishikawa, Toshihisa

N1 - Funding Information: The authors cordially thank Prof. Kazumitsu Ueda (Kyoto Univ.) for generously providing us with MDR KB-G2 and parental KB-3-1 cells. This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (No. 14103013 to T.T.) as well as a research grant (No. 13NP0401 to T.I.) for Creative Scientific Research from the Japan Society for the Promotion of Science.

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Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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