Synthesis and domino metathesis of functionalized 7-oxanorbornene analogs toward cis-fused heterocycles

Minoru Ikoma, Masato Oikawa, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Here, we report our strategy to synthesize structurally diverse cis-fused heterocycles via 7-oxanorbornene analogs. By the intramolecular Diels-Alder reaction of 3-iodoacrylamide, followed by the domino metathesis reaction, the cis-fused heterobicyclic skeleton was efficiently constructed in 5-8 steps.

Original languageEnglish
Pages (from-to)2740-2749
Number of pages10
JournalTetrahedron
Volume64
Issue number12
DOIs
Publication statusPublished - 2008 Mar 17

Keywords

  • 7-Oxanorbornene
  • Cis-fused heterocycle
  • Diels-Alder reaction
  • Domino metathesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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