TY - JOUR
T1 - Synthesis and cataleptic effects of optically active dihydrohaloperidols and dihydrobromoperidols
AU - Takeshita, Mitsuhiro
AU - Miura, Masatomo
AU - Hongo, Takahiko
AU - Ohkubo, Tadashi
AU - Sugawara, Kazunobu
AU - Kosaka, Kazuhiko
AU - Araki, Tsutomu
AU - Oshima, Yoshiteru
PY - 1997
Y1 - 1997
N2 - Optically active dihydrohaloperidols and dihydrobromoperidols, the major metabolites of haloperidol and bromoperidol, clinically used as neuroleptic drugs in humans, were asymmetrically synthesized by Jaen's method. The motor effects of all the reduced haloperidol and bromoperidol metabolites were evaluated by the mouse catalepsy test. The results indicate that administration of the optically active dihydrohaloperidols and dihydrobromoperidols as well as haloperidol and bromoperidol can cause significant motor deficits in mice.
AB - Optically active dihydrohaloperidols and dihydrobromoperidols, the major metabolites of haloperidol and bromoperidol, clinically used as neuroleptic drugs in humans, were asymmetrically synthesized by Jaen's method. The motor effects of all the reduced haloperidol and bromoperidol metabolites were evaluated by the mouse catalepsy test. The results indicate that administration of the optically active dihydrohaloperidols and dihydrobromoperidols as well as haloperidol and bromoperidol can cause significant motor deficits in mice.
KW - (R)- dihydrobromoperidol
KW - (R)-dihydrohaloperidol
KW - (S)-dihydrobromoperidol
KW - (S)-dihydrohaloperidol
KW - Catalepsy
KW - Dyskinesia
KW - Motor deficit
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U2 - 10.1002/(SICI)1520-636X(1997)9:5/6<443::AID-CHIR8>3.0.CO;2-6
DO - 10.1002/(SICI)1520-636X(1997)9:5/6<443::AID-CHIR8>3.0.CO;2-6
M3 - Article
C2 - 9329176
AN - SCOPUS:0030923472
VL - 9
SP - 443
EP - 445
JO - Chirality
JF - Chirality
SN - 0899-0042
IS - 5-6
ER -