Synthesis and biological property of carba and 20-deoxo analogues of arenastatin A

Nobutoshi Murakami, Weiqi Wang, Satoru Tamura, Motomasa Kobayashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1823-1826
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number16
DOIs
Publication statusPublished - 2000 Aug 21

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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