TY - JOUR
T1 - Synthesis and biological property of carba and 20-deoxo analogues of arenastatin A
AU - Murakami, Nobutoshi
AU - Wang, Weiqi
AU - Tamura, Satoru
AU - Kobayashi, Motomasa
N1 - Funding Information:
The authors are grateful to the Naito Foundation, the Houansha Foundation, and the Ministry of Education, Sciences, Sports, and Culture of Japan for financial support.
PY - 2000/8/21
Y1 - 2000/8/21
N2 - The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility. (C) 2000 Elsevier Science Ltd. All rights reserved.
AB - The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility. (C) 2000 Elsevier Science Ltd. All rights reserved.
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U2 - 10.1016/S0960-894X(00)00356-5
DO - 10.1016/S0960-894X(00)00356-5
M3 - Article
C2 - 10969977
AN - SCOPUS:0034698864
VL - 10
SP - 1823
EP - 1826
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 16
ER -