Synthesis and biological property of carba and 20-deoxo analogues of arenastatin A

Nobutoshi Murakami; Weiqi Wang; Satoru Tamura; Motomasa Kobayashi

doi:10.1016/S0960-894X(00)00356-5

Synthesis and biological property of carba and 20-deoxo analogues of arenastatin A

Nobutoshi Murakami, Weiqi Wang, Satoru Tamura, Motomasa Kobayashi

SCI - Chemistry

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	1823-1826
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(00)00356-5
Publication status	Published - 2000 Aug 21

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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AU - Wang, Weiqi

AU - Tamura, Satoru

AU - Kobayashi, Motomasa

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