Synthetic and biological studies continued in our laboratories con- tributed to elucidate the chemical structure and biological functions of en-dotoxin, which is lipopolysaccharide (LPS) located at the cell surface of gram-negative bacteria. In this paper the effect of structural variation on the biological activities is discussed of lipophilic part of LPS. The recent result of our synthetic approach toward the most simple LPS isolated and characterized from Escherichia coli Re mutant cells is also described.
ASJC Scopus subject areas
- Chemical Engineering(all)