Synthesis and biological function of bacterial endotoxin

Shoichi Kusumoto, Naoto Kusunose, Masahiro Imoto, Tetsuo Shimamoto, T. Takashi, K. Kamikawa, Tetsuo Shiba, Haruhiko Takada, Shozo Kotani, E. Th Rietschel

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Synthetic and biological studies continued in our laboratories con- tributed to elucidate the chemical structure and biological functions of en-dotoxin, which is lipopolysaccharide (LPS) located at the cell surface of gram-negative bacteria. In this paper the effect of structural variation on the biological activities is discussed of lipophilic part of LPS. The recent result of our synthetic approach toward the most simple LPS isolated and characterized from Escherichia coli Re mutant cells is also described.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalPure and Applied Chemistry
Issue number3
Publication statusPublished - 1989 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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