Synthesis and biological evaluation of gambierol analogues

Haruhiko Fuwa, Noriko Kainuma, Masayuki Satake, Makoto Sasaki

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.

Original languageEnglish
Pages (from-to)2519-2522
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number15
DOIs
Publication statusPublished - 2003 Aug 4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis and biological evaluation of gambierol analogues'. Together they form a unique fingerprint.

  • Cite this