Synthesis and biological evaluation of analogs of the marine toxin polycavernoside A

Louis Barriault, Serge L. Boulet, Kenshu Fujiwara, Akio Murai, Leo A. Paquette, Mari Yotsu-Yamashita

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Second generation analogs of polycavernoside A (2) possessing a side chain at C-15 different from that of the natural toxin have been synthesized. The in vivo toxicities of these new compounds (expressed as the minimal lethal dose) have been evaluated in mice (ip) and compared to 2, its aglycone (8), and polycavernoside B (9). The bioactivity profile of enynene 5 is particularly notable.

Original languageEnglish
Pages (from-to)2069-2072
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number14
DOIs
Publication statusPublished - 1999 Jul 19

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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