Synthesis and biological evaluation of analogs of the marine toxin polycavernoside A

Louis Barriault, Serge L. Boulet, Kenshu Fujiwara, Akio Murai, Leo A. Paquette, Mari Yotsu-Yamashita

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Second generation analogs of polycavernoside A (2) possessing a side chain at C-15 different from that of the natural toxin have been synthesized. The in vivo toxicities of these new compounds (expressed as the minimal lethal dose) have been evaluated in mice (ip) and compared to 2, its aglycone (8), and polycavernoside B (9). The bioactivity profile of enynene 5 is particularly notable.

    Original languageEnglish
    Pages (from-to)2069-2072
    Number of pages4
    JournalBioorganic and Medicinal Chemistry Letters
    Volume9
    Issue number14
    DOIs
    Publication statusPublished - 1999 Jul 19

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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