TY - JOUR
T1 - Synthesis and biological evaluation of 9-(t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl)-9h-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.1)
AU - Katagiri, Nobuya
AU - Sato, Hiroshi
AU - Kaneko, Chikara
N1 - Funding Information:
This work was supported by the Grant-in-Aid for Scientific Research on Priority Areas No. 03242104 from the Ministry of Education, Science and Culture, Japan.
PY - 1992/2/1
Y1 - 1992/2/1
N2 - Adenine (7 and 16). thymine (9a and 18a). and 5-fluorouracil (9b and 18b) involving t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl- and t-2, t-3-bishydroxymethyl-r-1-cyclopropylmethyl residues were synthesized, starting from trans-t, 4-dibenzyloxy-2-butene and its cis isomer, respectively. These compounds were evaluated for anti HSV-1 activity.
AB - Adenine (7 and 16). thymine (9a and 18a). and 5-fluorouracil (9b and 18b) involving t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl- and t-2, t-3-bishydroxymethyl-r-1-cyclopropylmethyl residues were synthesized, starting from trans-t, 4-dibenzyloxy-2-butene and its cis isomer, respectively. These compounds were evaluated for anti HSV-1 activity.
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U2 - 10.1080/07328319208021735
DO - 10.1080/07328319208021735
M3 - Article
AN - SCOPUS:0026596153
VL - 11
SP - 707
EP - 718
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
SN - 0732-8311
IS - 2-4
ER -