Synthesis and biological evaluation of 9-(t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl)-9h-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.1)

Nobuya Katagiri; Hiroshi Sato; Chikara Kaneko

doi:10.1080/07328319208021735

Synthesis and biological evaluation of 9-(t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl)-9h-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.1)

Nobuya Katagiri, Hiroshi Sato, Chikara Kaneko

PHA - Pharmacy

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

Adenine (7 and 16). thymine (9a and 18a). and 5-fluorouracil (9b and 18b) involving t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl- and t-2, t-3-bishydroxymethyl-r-1-cyclopropylmethyl residues were synthesized, starting from trans-t, 4-dibenzyloxy-2-butene and its cis isomer, respectively. These compounds were evaluated for anti HSV-1 activity.

Original language	English
Pages (from-to)	707-718
Number of pages	12
Journal	Nucleosides and Nucleotides
Volume	11
Issue number	2-4
DOIs	https://doi.org/10.1080/07328319208021735
Publication status	Published - 1992 Feb 1

ASJC Scopus subject areas

Biochemistry
Genetics

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abstract = "Adenine (7 and 16). thymine (9a and 18a). and 5-fluorouracil (9b and 18b) involving t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl- and t-2, t-3-bishydroxymethyl-r-1-cyclopropylmethyl residues were synthesized, starting from trans-t, 4-dibenzyloxy-2-butene and its cis isomer, respectively. These compounds were evaluated for anti HSV-1 activity.",

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T1 - Synthesis and biological evaluation of 9-(t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl)-9h-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.1)

AU - Katagiri, Nobuya

AU - Sato, Hiroshi

AU - Kaneko, Chikara

PY - 1992/2/1

Y1 - 1992/2/1

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AB - Adenine (7 and 16). thymine (9a and 18a). and 5-fluorouracil (9b and 18b) involving t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl- and t-2, t-3-bishydroxymethyl-r-1-cyclopropylmethyl residues were synthesized, starting from trans-t, 4-dibenzyloxy-2-butene and its cis isomer, respectively. These compounds were evaluated for anti HSV-1 activity.

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