Synthesis and biological evaluation of 9-(t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl)-9h-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.1)

Nobuya Katagiri, Hiroshi Sato, Chikara Kaneko

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Adenine (7 and 16). thymine (9a and 18a). and 5-fluorouracil (9b and 18b) involving t-2, c-3-bishydroxymethyl-r-1-cyclopropylmethyl- and t-2, t-3-bishydroxymethyl-r-1-cyclopropylmethyl residues were synthesized, starting from trans-t, 4-dibenzyloxy-2-butene and its cis isomer, respectively. These compounds were evaluated for anti HSV-1 activity.

Original languageEnglish
Pages (from-to)707-718
Number of pages12
JournalNucleosides and Nucleotides
Volume11
Issue number2-4
DOIs
Publication statusPublished - 1992 Feb 1

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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