Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

Ayano Takeuchi, Makihito Hori, Shinichi Sato, Hyun Seung Ban, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Takao Yamori, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.

Original languageEnglish
Pages (from-to)1455-1461
Number of pages7
JournalMedChemComm
Volume3
Issue number11
DOIs
Publication statusPublished - 2012 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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