Synthesis and biological activity of dysiherbaine model compound

Makoto Sasaki, Takahiro Maruyama, Ryuichi Sakai, Kazuo Tachibana

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Synthesis of dysiherbaine model compound 2 and its diastereomer 3 is described. The structurally simplified model compound 2, lacking the hydroxyl and N-methyl groups on the tetrahydropyran ring, induced convulsive behavior in mice upon intracerebral injections.

Original languageEnglish
Pages (from-to)3195-3198
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number16
DOIs
Publication statusPublished - 1999 Apr 16

Keywords

  • Amino acids and derivatives
  • Marine metabolites
  • Natural products
  • Toxins

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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