Abstract
Synthesis of dysiherbaine model compound 2 and its diastereomer 3 is described. The structurally simplified model compound 2, lacking the hydroxyl and N-methyl groups on the tetrahydropyran ring, induced convulsive behavior in mice upon intracerebral injections.
Original language | English |
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Pages (from-to) | 3195-3198 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 16 |
DOIs | |
Publication status | Published - 1999 Apr 16 |
Keywords
- Amino acids and derivatives
- Marine metabolites
- Natural products
- Toxins
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry