Synthesis and biological activities of reveromycin A and spirofungin A derivatives

Takeshi Shimizu, Takeo Usui, Makoto Fujikura, Makoto Kawatani, Tomoharu Satoh, Kiyotaka Machida, Naoki Kanoh, Je Tae Woo, Hiroyuki Osada, Mikiko Sodeoka

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of srcts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.

Original languageEnglish
Pages (from-to)3756-3760
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number13
DOIs
Publication statusPublished - 2008 Jul 1

Keywords

  • Isoleucyl-tRNA synthetase
  • Osteoclasts
  • Reveromycin A
  • Spirofungin A
  • src-NRK cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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