Synthesis and biological activities of cyclopropenone antibiotic penitricin and congeners

Hidetoshi Tokuyama, Masahiko Isaka, Eiichi Nakamura, Ryoichi Ando, Yasuhiro Morinaka

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A number of derivatives of the cyclopropenone antibiotic penitricin have been synthesized by the reaction of metalated cyclopropenone acetals with electrophiles. Studies on the antimicrobial structure-activity relationships indicated that the penitricin skeleton, hydroxymethylcyclopropenone, is indispensable for antimicrobial activity. These compounds were also found to display cytotoxic activity.

Original languageEnglish
Pages (from-to)1148-1154
Number of pages7
Journalthe journal of antibiotics
Volume45
Issue number7
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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