Synthesis and biolgical analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer

Hisatsugu Ohori, Hiroyuki Yamakoshi, Masaki Tomizawa, Masatoshi Shibuya, Yuichi Kakudo, Atsuko Takahashi, Shin Takahashi, Satoshi Kato, Takao Suzuki, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)

Abstract

Curcumin (diferuloylmethane) is a dietary phytochemical with low toxicity that exhibits growth-suppressive activity against a variety of cancer cells and possesses certain chemopreventive properties. Curcumin has already been the subject of several clinical trials for use as a treatment in human cancers. Synthetic chemical modifications of curcumin have been studied intensively in an attempt to find a molecule with similar but enhanced properties of curcumin. In this study, a series of novel curcumin analogues were synthesized and screened for anticancer activity. New analogues that exhibit growth-suppressive activity 30 times that of curcumin and other commonly used anticancer drugs were identified. Structurally, the new analogues are symmetrical 1,5-diarylpentadienone whose aromatic rings possess an alkoxy substitution at each of the positions 3 and 5. Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of β-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect. The analogues, however, exhibited neither harmful nor growth-suppresive effects on normal hepatocytes where oncogene products are not activated. They also exhibited no toxicities in vivo that they may provide effective alternative therapies for the prevention and treatment of some human cancers.

Original languageEnglish
Pages (from-to)2563-2571
Number of pages9
JournalMolecular Cancer Therapeutics
Volume5
Issue number10
DOIs
Publication statusPublished - 2006 Oct

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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