Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi, Takayuki Oritani, Hiromasa Kiyota

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

    Original languageEnglish
    Pages (from-to)1529-1538
    Number of pages10
    JournalTetrahedron
    Volume59
    Issue number9
    DOIs
    Publication statusPublished - 2003 Feb 24

    Keywords

    • Antitumor activity
    • Taxinine
    • Taxol
    • m-azidobenzoyl

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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