Synthesis and Anti-HIV Activity of 9-[c-4,t-5-Bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine

Nobuya Katagiri, Masahiro Nomura, Hiroshi Sato, Chikara Kaneko, Keisuke Yusa, Takashi Tsuruo

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


The synthesis and in vitro anti-HIV activity of two new racemic nucleoside analogues are described; namely, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-y1]-9H-adenine (12) and its guanine analogue 18. While the latter (18) showed no activity, the therapeutic index of the former (12) was 200 and comparable to that (400) of carbovir. One enantiomer of 12 may be viewed as an analogue of carbocyclic oxetanocin and the other as an analogue of carbovir. Hence, these results indicate that one or both of the individual enantiomers of 12 could serve as candidates or lead compounds for the development of anti-AIDS agents.

Original languageEnglish
Pages (from-to)1882-1886
Number of pages5
JournalJournal of Medicinal Chemistry
Issue number10
Publication statusPublished - 1992 May 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


Dive into the research topics of 'Synthesis and Anti-HIV Activity of 9-[c-4,t-5-Bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine'. Together they form a unique fingerprint.

Cite this