Synthesis and absolute stereochemistry of tanzawaic acid (GS-1302)

Hirokazu Arimoto, Kazuya Nishimura, Makoto Kuramoto, Daisuke Uemura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The first total synthesis of tanzawaic acid A(GS-1302-3) is described. The stereocontrolled synthetic route allowes the absolute stereochemistry to be determined. One key transformation in the sequence involves a Stille coupling with a highly hindered aryl triflate. Examples and results of several coupling reactions are also included.

Original languageEnglish
Pages (from-to)9513-9516
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number51
DOIs
Publication statusPublished - 1998 Dec 17
Externally publishedYes

Keywords

  • Biologically active compounds
  • Carboxylic acids and derivatives
  • Stereochemistry
  • Stille coupling reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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