The first total synthesis of tanzawaic acid A(GS-1302-3) is described. The stereocontrolled synthetic route allowes the absolute stereochemistry to be determined. One key transformation in the sequence involves a Stille coupling with a highly hindered aryl triflate. Examples and results of several coupling reactions are also included.
- Biologically active compounds
- Carboxylic acids and derivatives
- Stille coupling reactions
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry