Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

Takanori Sugimoto; Tomohiko Fujii; Yasumaru Hatanaka; Shosuke Yamamura; Minoru Ueda

doi:10.1016/S0040-4039(02)01460-0

Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

Takanori Sugimoto, Tomohiko Fujii, Yasumaru Hatanaka, Shosuke Yamamura, Minoru Ueda

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10^-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.

Original language	English
Pages (from-to)	6529-6532
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	37
DOIs	https://doi.org/10.1016/S0040-4039(02)01460-0
Publication status	Published - 2002 Sep 9
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants",

abstract = "Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.",

author = "Takanori Sugimoto and Tomohiko Fujii and Yasumaru Hatanaka and Shosuke Yamamura and Minoru Ueda",

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T1 - Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

AU - Sugimoto, Takanori

AU - Fujii, Tomohiko

AU - Hatanaka, Yasumaru

AU - Yamamura, Shosuke

AU - Ueda, Minoru

PY - 2002/9/9

Y1 - 2002/9/9

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AB - Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.

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