Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

Takanori Sugimoto; Tomohiko Fujii; Yasumaru Hatanaka; Shosuke Yamamura; Minoru Ueda

doi:10.1016/S0040-4039(02)01460-0

Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

Takanori Sugimoto, Tomohiko Fujii, Yasumaru Hatanaka, Shosuke Yamamura, Minoru Ueda

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10^-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.

Original language	English
Pages (from-to)	6529-6532
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	37
DOIs	https://doi.org/10.1016/S0040-4039(02)01460-0
Publication status	Published - 2002 Sep 9
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants",

abstract = "Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.",

author = "Takanori Sugimoto and Tomohiko Fujii and Yasumaru Hatanaka and Shosuke Yamamura and Minoru Ueda",

note = "Funding Information: The authors are indebted to the Ministry of Education, Science, Sports and Culture (Japan) for Grant-in-Aid for Scientific Research (No. 1302467 and 12680598), Pioneering Research Project in Biotechnology given by the Ministry of Agriculture, Forestry and Fisheries, Kato Memorial Bioscience Foundation, Naito Foundation, Kurata Foundation, and Moritani Foundation for financial support.",

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doi = "10.1016/S0040-4039(02)01460-0",

language = "English",

volume = "43",

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journal = "Tetrahedron Letters",

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publisher = "Elsevier Limited",

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T1 - Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

AU - Sugimoto, Takanori

AU - Fujii, Tomohiko

AU - Hatanaka, Yasumaru

AU - Yamamura, Shosuke

AU - Ueda, Minoru

N1 - Funding Information: The authors are indebted to the Ministry of Education, Science, Sports and Culture (Japan) for Grant-in-Aid for Scientific Research (No. 1302467 and 12680598), Pioneering Research Project in Biotechnology given by the Ministry of Agriculture, Forestry and Fisheries, Kato Memorial Bioscience Foundation, Naito Foundation, Kurata Foundation, and Moritani Foundation for financial support.

PY - 2002/9/9

Y1 - 2002/9/9

N2 - Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.

AB - Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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ER -

Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

Abstract

ASJC Scopus subject areas

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