Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants

Takanori Sugimoto, Tomohiko Fujii, Yasumaru Hatanaka, Shosuke Yamamura, Minoru Ueda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.

Original languageEnglish
Pages (from-to)6529-6532
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number37
DOIs
Publication statusPublished - 2002 Sep 9
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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