Abstract
Novel and non-radioactive photoaffinity probes (1 and 2) for the bioorganic study of nyctinasty are designed and synthesized based on potassium isolespedezate (3), which induce leaf-opening against the leaf of Cassia mimosoides L. These probes bear a trifluoromethyldiazirine or diazophenyl group for photoaffinity and a biotin subunit for affinity chromatography and chemiluminescent detection. Probes (1 and 2) showed leaf-opening activity at 5×10-5 mol/L with leaves of C. mimosoides; thus, they would be an important tool for the identification of a receptor protein for 3.
Original language | English |
---|---|
Pages (from-to) | 6529-6532 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 37 |
DOIs | |
Publication status | Published - 2002 Sep 9 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry