Synovitis in a patient with IgG4-related disease

Fumiko Tomiyama, Ryu Watanabe, Hiroshi Fujii, Yukiko Kamogawa, Yoko Fujita, Yuko Shirota, Takashi Nakamichi, Hiroshi Sato, Tomonori Ishii, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 71-year-old man was admitted to our department due to arthralgia and renal dysfunction. A physical examination disclosed swelling of the right shoulder and left wrist joints. Laboratory tests showed elevated serum IgG4 and creatinine levels, and magnetic resonance imaging of the wrist revealed bone erosion and synovitis. In addition, fluorodeoxyglucose positron emission tomography showed uptake in the submandibular glands, pancreas, kidneys, and affected joints and a renal biopsy revealed tubulointerstitial nephritis with the infiltration of IgG4+ plasma cells. The patient was subsequently diagnosed with IgG4-related disease (IgG4RD) and successfully treated with corticosteroid therapy. This case suggests that erosive arthritis may occur in patients with IgG4-RD.

Original languageEnglish
Pages (from-to)1427-1432
Number of pages6
JournalInternal Medicine
Issue number11
Publication statusPublished - 2015 Jun 1


  • IgG4-related disease
  • Rheumatoid arthritis
  • Synovitis

ASJC Scopus subject areas

  • Internal Medicine


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