Symptom-specific quality of life in patients with benign prostatic hyperplasia

Koji Yoshimura, Yoichi Arai, Kentaro Ichioka, Naoki Terada, Yosuke Matsuta, Kazutoshi Okubo

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Background: We investigated which factors are most bothersome to preoperative patients with benign prostatic hyperplasia (BPH). Methods: A total of 423 newly diagnosed patients and 388 preoperative patients with symptomatic BPH were evaluated. International prostate symptom score (IPSS) and IPSS quality-of-life (QOL) assessment score were used for assessment of symptoms and symptom-specific QOL of the patients with BPH. Uroflow variables were measured in all patients. Other objective variables such as prostate volume, transition zone volume, Schaefer's obstruction grade, and detrusor pressure at maximal urinary flow were evaluated in 209 preoperative patients. We analyzed the relationships between symptom-specific QOL and other variables. Statistical analyses were performed using Spearman's correlation coefficient and a stepwise linear regression model. Results: Symptom-specific QOL scores had moderate to good correlation with IPSS (P < 0.0001; r = 0.525-0.560). Filling symptom subscore had a slightly greater impact on symptom-specific QOL than voiding subscore in both groups of patients. Weak stream, feeling of incomplete emptying, and nocturia significantly decreased symptom-specific QOL in both groups of patients. While newly diagnosed patients suffered from frequency as well, urgency had the strongest impact on symptom-specific QOL of preoperative patients. Objectively measurable variables had no association with symptom-specific QOL. Conclusion: Japanese patients with BPH generally suffer from weak stream, feeling of incomplete emptying, and nocturia in all disease phases. Frequency is problematic for newly diagnosed patients and urgency is problematic for preoperative patients as well. Symptom-specific QOL of BPH patients cannot be estimated by physically measurable variables.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalInternational Journal of Urology
Issue number9
Publication statusPublished - 2002


  • Benign prostatic hyperplasia
  • Bladder outlet obstruction
  • Lower urinary tract symptoms
  • Quality of life

ASJC Scopus subject areas

  • Urology


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