TY - JOUR
T1 - Switching of the Laryngeal Cavity from the Respiratory Diverticulum to the Vestibular Recess
T2 - A Study Using Serial Sagittal Sections of Human Embryos and Fetuses
AU - Yamamoto, Masahito
AU - Honkura, Yohei
AU - Rodríguez-Vázquez, Jose Francisco
AU - Murakami, Gen
AU - Katori, Yukio
AU - Cho, Baik Hwan
AU - Abe, Shin Ichi
N1 - Funding Information:
This research was supported by Oral Health Science Center Grant hrc8 from Tokyo Dental College and by a Project for Private Universities matching fund subsidy from MEXT (Ministry of Education, Culture, Sports, Science and Technology), Japan, 2010–2012.
Publisher Copyright:
© 2016 The Voice Foundation.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - A cecum-like protrusion of the pharynx (the laryngeal cecum or vestibular recess [VR]) develops immediately anterior to the laryngeal part of the respiratory diverticulum. An expansion of the VR has been well described, whereas the fate of the diverticulum is still obscure, although its pharyngeal opening corresponds to the glottis. We observed sagittal sections of 10 embryos (five specimens at 5-6 weeks and another five at 7-8 weeks) and eight fetuses at 25-30 weeks. At 5-6 weeks, a lumen of the laryngeal part of the respiratory diverticulum appeared, and subsequently, the VR opened into the epithelial lamina. Because of this discrete separation, it seemed unlikely that the pharyngeal pouches contributed to the laryngeal epithelium. At 6-7 weeks, the VR exhibited a high boot-shaped lumen with canalization to the diverticular lumen at the level of the cricoid cartilage. Thus, in a midline area between the bilateral arytenoid cartilages, double laryngeal lumina were evident, separated by the thick midline epithelial lamina. At 25-30 weeks, the inferior part of the VR lumen had become enlarged because of the destruction of the epithelial lamina along the arytenoid and corniculate cartilages. In contrast, candidates for the initial diverticular lumen remained as epithelial slits in the anterosuperior side of the transverse arytenoid muscle. Therefore, the final anterior and lateral laryngeal walls seemed to originate from the VR with canalization, in contrast to the part of the posterior wall derived from the initial diverticular wall.
AB - A cecum-like protrusion of the pharynx (the laryngeal cecum or vestibular recess [VR]) develops immediately anterior to the laryngeal part of the respiratory diverticulum. An expansion of the VR has been well described, whereas the fate of the diverticulum is still obscure, although its pharyngeal opening corresponds to the glottis. We observed sagittal sections of 10 embryos (five specimens at 5-6 weeks and another five at 7-8 weeks) and eight fetuses at 25-30 weeks. At 5-6 weeks, a lumen of the laryngeal part of the respiratory diverticulum appeared, and subsequently, the VR opened into the epithelial lamina. Because of this discrete separation, it seemed unlikely that the pharyngeal pouches contributed to the laryngeal epithelium. At 6-7 weeks, the VR exhibited a high boot-shaped lumen with canalization to the diverticular lumen at the level of the cricoid cartilage. Thus, in a midline area between the bilateral arytenoid cartilages, double laryngeal lumina were evident, separated by the thick midline epithelial lamina. At 25-30 weeks, the inferior part of the VR lumen had become enlarged because of the destruction of the epithelial lamina along the arytenoid and corniculate cartilages. In contrast, candidates for the initial diverticular lumen remained as epithelial slits in the anterosuperior side of the transverse arytenoid muscle. Therefore, the final anterior and lateral laryngeal walls seemed to originate from the VR with canalization, in contrast to the part of the posterior wall derived from the initial diverticular wall.
KW - Human embryo
KW - Laryngeal cecum
KW - Laryngeal ventricle
KW - Pharyngeal pouch
KW - Respiratory diverticulum
KW - Vestibular recess
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U2 - 10.1016/j.jvoice.2015.05.003
DO - 10.1016/j.jvoice.2015.05.003
M3 - Article
C2 - 26154762
AN - SCOPUS:84934783485
VL - 30
SP - 263
EP - 271
JO - Journal of Voice
JF - Journal of Voice
SN - 0892-1997
IS - 3
ER -