Sustainable conjugate addition of indoles catalyzed by acidic ionic liquid immobilized on silica

Hisahiro Hagiwara, Masayoshi Sekifuji, Takashi Hoshi, Toshio Suzuki, Bao Quanxi, Kun Kyo, Chiaki Yokoyama

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A new protocol for 1,4-conjugate addition of indoles to vinyl ketones has been developed, employing Lewis acidic ionic liquid immobilized on silica, ILIS-SO2Cl, as a catalyst, which exhibited an efficient, mild and recyclable nature. The reaction condition is applicable to various vinyl ketones and indoles. The mild nature of the reaction condition showed that the acetoxy or TBDMS group in indoles was maintained intact. The catalyst was used six times resulting in 86% average yield.

Original languageEnglish
Pages (from-to)608-610
Number of pages3
JournalSynlett
Issue number4
DOIs
Publication statusPublished - 2008 Mar 3

Keywords

  • Catalysis
  • Indoles
  • Ionic liquids
  • Michael additions
  • Supported catalysis

ASJC Scopus subject areas

  • Organic Chemistry

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