Susceptibility Loci to autoimmune arthritis in MRL/lpr Mice

Junji Kamogawa, Miho Terada, Miyuki Nishihara, Shinichi Mizuki, Shiro Mori, Syuichi Nakatsuru, Yusuke Nakamura, Masato Nose

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Using MRL / Mp-lpr / lpr mouse that spontaneously develops pathology and pathology very similar to human collagen disease including RA, a locus defining the onset of arthritis is classified as C3H / HeJ-lpr that does not develop collagen disease / Lpr mice and mapped them.The results showed that arthritis is dominated by multiple susceptibility and resistance loci and there is additive and hierarchical existence between these susceptibility loci Moreover, these are mapped to a region different from the disease susceptibility locus of salivary glanditis, vasculitis, nephritis, RA is dominated by genes that can be genetically separated from other collagen diseases These findings suggest that RA is an important fact in simulating RA as a polygenic disease and explaining the origins of disease image diversity of collagen diseases.

Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalJapanese Journal of Clinical Immunology
Volume22
Issue number6
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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