Investigations on emergence of vancomycin-resistant Enterococciis faecium (VREF) which has recently been attracting attention, especially in the Western contries, have been conducted in Japan. A total of 1,239 isolates ofE.faecium were collected from 19 institutions during the period of April 1995 and June 1996, in the purpose of evaluating susceptibilities to variety of antimicrobial agents, including RP59500 and vancomycin (VCM), and detecting vancomycin-resistant genes (van genes). Susceptibilities of penicillin-resistant Streptococcuspneumoniae (PRSP) and methicillin-resistant Staphylococctis aweus (MRSA) were also studied. As a result, 2 isolates of E.faecium were found to be moderately resistant to VCM showing MIC of 8/fg/ml though the final identification in species level and the detection of van genes by PCR method have not been completed. On the other hand, there detected no MRSA nor PRSP showing moderately resistant or resistant to VCM. It was concluded that RP59500 and VCM possessed favorable activity against clinically isolated E. faeciiim, PRSP and MRSA. Among other species of enterococci, moderately resistant strains to VCM showing MIC of 8/ig/ml were detected; 10 isolates of E. gallinarum, 4 of E. casseliflavus and 2 of E. flavescens. In those isolates , vanCl and \anC2 were detected by PCR, and vanB was also detected in a isolates ofE. gallinamm simultaneously.
|Number of pages||2|
|Journal||Japanese Journal of Antibiotics|
|Publication status||Published - 1999 Dec 1|
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases