Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005)

Hajime Goto, Hideki Takeda, Shin Kawai, Suguru Watanabe, Mitsuhiro Okazaki, Kaoru Shimada, Kunio Nakano, Hiroshi Yokouchi, Takeshi Mori, Jun Igari, Toyoko Oguri, Makoto Yamamoto, Hiroshi Inoue, Toshihide Nakadate, Akira Suwabe, Yugo Ashino, Nobuki Aoki, Yasuo Honma, Yasutoshi Suzuki, Yasuo KarasawaKouichiro Kudo, Nobuyuki Kobayashi, Tsukasa Tanaka, Kunihiko Yoshimura, Masaaki Kawabata, Yoshitaka Nakamori, Midori Sumitomo, Mikio Oka, Yoshihiro Kobashi, Shigeru Kohno, Yoichi Hirakata, Akira Kondou, Junichi Matsuda, Michiko Nakano, Satoru Oikawa

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Abstract

From October 2005 to September 2006, we collected the specimen from 366 patients with lower respiratory tract infections in 12 institutions in Japan, and investigated the susceptibilities of isolated bacteria to various antibacterial agents and patients' characteristics. Of 411 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in infection, 406 strains were examined. The isolated bacteria were: Staphylococcus aureus 70, Streptococcus pneumoniae 85, Haemophilus influenzae 78, Pseudomonas aeruginosa (non-mucoid) 46, P. aeruginosa (mucoid) 14, Klebsiella pneumoniae 21, and Moraxella subgenus Branhamella catarrhalis 40. Of 70 S. aureus strains, those with 2 μg/ml or less of MIC of oxacillin (methicillin-susceptible S. aureus: MSSA) and those with 4 μg/ml or more of MIC of oxacillin (methicillin-resistant S. aureus: MRSA) were 38 (54.3%) and 32 (45.7%) strains, respectively. Against MSSA, imipenem had the most potent antibacterial activity and inhibited the growth of 37 strains (97.4%) at 0.063 μg/ml or less. Against MRSA, arbekacin and vancomycin showed the most potent activity and inhibited the growth of all the strains at 1 μg/ml. Carbapenems showed the most potent activities against S. pneumoniae and in particular, panipenem inhibited the growth of all the strains at 0.063 μg/ml or less. Faropenem also had a preferable activity and inhibited the growth of all the strains at 0.25 μg/ml. In contrast, there were high-resistant strains (MIC: over 128 μg/ml) for erythromycin (38.1%) and clindamycin (22.6%). Against H. influenzae, levofloxacin showed the most potent activity and its MIC 90 was 0.063 μg/ml or less. Meropenem showed the most potent activity against P. aeruginosa (mucoid) and its MIC90 was 0.5 μg/ml. Against P. aeruginosa (non-mucoid), arbekacin had the most potent activity and its MIC90 was 8 μg/ml. Against K. pneumoniae, cefozopran was the most potent activity and inhibited the growth of all the strains at 0.063 μg/ml or less. Also, all the antibacterial agents except ampicillin generally showed a potent activity against M. (B.) catarrhalis and the MIC90 of them were 2 μg/ml or less. The approximately half the number (53.6%) of the patients with respiratory infection were aged 70 years or older. Bacterial pneumonia and chronic bronchitis accounted for 44.3% and 29.8% of all the respiratory infection, respectively. The bacteria frequently isolated from the patients with bacterial pneumonia were S. aureus (15.4%), S. pneumoniae (23.4%), and H. influenzae (21.3%). S. aureus (25.4%) and S. pneumoniae (18.0%) also were frequently isolated from the patients with chronic bronchitis. Before the drug administration, the bacteria frequently isolated from the patients were S. pneumoniae (22.0%) and H. influenzae (21.4%). The bacteria frequently isolated from the patients treated with macrolides were S. pneumoniae and P. aeruginosa, and their isolation frequencies were each 35.3%.

Original languageEnglish
Pages (from-to)209-240
Number of pages32
JournalThe Japanese Journal of Antibiotics
Volume61
Issue number4
Publication statusPublished - 2008 Aug

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Goto, H., Takeda, H., Kawai, S., Watanabe, S., Okazaki, M., Shimada, K., Nakano, K., Yokouchi, H., Mori, T., Igari, J., Oguri, T., Yamamoto, M., Inoue, H., Nakadate, T., Suwabe, A., Ashino, Y., Aoki, N., Honma, Y., Suzuki, Y., ... Oikawa, S. (2008). Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005). The Japanese Journal of Antibiotics, 61(4), 209-240.