Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians

Y. Iwasaki, M. Mimuro, M. Yoshida, T. Kitamoto, Y. Hashizume

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: It is not known whether the clinical course of Japanese sporadic Creutzfeldt-Jakob disease (sCJD) cases differs from that of Caucasian sCJD cases. Patients and methods: To investigate the clinical course of Japanese sCJD, clinical findings from 29 patients with Japanese MM1-type sCJD were retrospectively evaluated and compared to Caucasian sCJD findings. Results: Survival of Japanese MM1-type sCJD up to the time of akinetic mutism state is similar to that of Caucasian subjects. However, the total disease duration of Japanese patients was approximately three times longer. Conclusions: The present observations indicate that Japanese sCJD cases generally show a longer disease duration because of the longer survival period after reaching the akinetic mutism state.

Original languageEnglish
Pages (from-to)999-1002
Number of pages4
JournalEuropean Journal of Neurology
Volume18
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • Akinetic mutism state
  • Creutzfeldt-Jakob disease
  • MM1-type
  • Myoclonus
  • Periodic sharp-wave complexes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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