TY - JOUR
T1 - Surveillance of patients with long-segment Barrett's esophagus
T2 - A multicenter prospective cohort study in Japan
AU - Matsuhashi, Nobuyuki
AU - Sakai, Eiji
AU - Ohata, Ken
AU - Ishimura, Norihisa
AU - Fujisaki, Junko
AU - Shimizu, Tomoki
AU - Iijima, Katsunori
AU - Koike, Tomoyuki
AU - Endo, Takao
AU - Kikuchi, Takefumi
AU - Inayoshi, Tatsuya
AU - Amano, Yuji
AU - Furuta, Takahisa
AU - Haruma, Ken
AU - Kinoshita, Yoshikazu
N1 - Publisher Copyright:
© 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background and Aim: The incidence of esophageal adenocarcinoma (EAC) in cases with long-segment Barrett's esophagus (BE) has not been investigated in Japan. The aim of this study is to investigate the incidence of EAC in Japanese cases with long-segment BE prospectively. Methods: This is a multicenter prospective cohort study investigating the incidence rate of EAC in patients with BE with a length of at least 3 cm. Study subjects received index esophagogastroduodenoscopy at the time of enrollment, and they were instructed to undergo yearly follow-up esophagogastroduodenoscopy. Patients in whom EAC was diagnosed in the endoscopic examinations underwent subsequent treatment, and their prognosis was observed. Results: Of 215 enrolled patients, six (2.8%) were initially diagnosed with EAC at the enrollment. Among the remaining 209 patients, 132 received at least one follow-up esophagogastroduodenoscopy. In this follow-up, three EACs developed in 251 observed patient-years (incidence rate: 1.2% per year). Most of the EACs detected at the initial endoscopic examination (5/6, 83%) were already at advanced stages. Meanwhile, all the three lesions detected in the follow-up esophagogastroduodenoscopies were identified as early cancers and subjected to curative resection. Conclusions: The incidence rate of EAC in Japanese cases with long-segment BE was calculated to be 1.2% in a year.
AB - Background and Aim: The incidence of esophageal adenocarcinoma (EAC) in cases with long-segment Barrett's esophagus (BE) has not been investigated in Japan. The aim of this study is to investigate the incidence of EAC in Japanese cases with long-segment BE prospectively. Methods: This is a multicenter prospective cohort study investigating the incidence rate of EAC in patients with BE with a length of at least 3 cm. Study subjects received index esophagogastroduodenoscopy at the time of enrollment, and they were instructed to undergo yearly follow-up esophagogastroduodenoscopy. Patients in whom EAC was diagnosed in the endoscopic examinations underwent subsequent treatment, and their prognosis was observed. Results: Of 215 enrolled patients, six (2.8%) were initially diagnosed with EAC at the enrollment. Among the remaining 209 patients, 132 received at least one follow-up esophagogastroduodenoscopy. In this follow-up, three EACs developed in 251 observed patient-years (incidence rate: 1.2% per year). Most of the EACs detected at the initial endoscopic examination (5/6, 83%) were already at advanced stages. Meanwhile, all the three lesions detected in the follow-up esophagogastroduodenoscopies were identified as early cancers and subjected to curative resection. Conclusions: The incidence rate of EAC in Japanese cases with long-segment BE was calculated to be 1.2% in a year.
KW - Barrett's esophagus (BE)
KW - esophageal adenocarcinoma (EAC)
KW - prospective cohort study
UR - http://www.scopus.com/inward/record.url?scp=85013298130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013298130&partnerID=8YFLogxK
U2 - 10.1111/jgh.13491
DO - 10.1111/jgh.13491
M3 - Article
C2 - 27416773
AN - SCOPUS:85013298130
VL - 32
SP - 409
EP - 414
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 2
ER -
