Surface structure and in vitro apatite-forming ability of titanium doped with various metals

Masakazu Kawashita, Yuta Iwabuchi, Kanae Suzuki, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Surface modification by sodium hydroxide (NaOH) and subsequent heat treatment can provide titanium and its alloys an apatite-forming ability in simulated body fluid (SBF), and is used clinically to treat titanium alloy hip joints in Japan. However, there is no systematic study on the relationship between the amount and chemical state of metals incorporated into titanium and the apatite-forming ability in SBF. We have studied this relationship herein by treating NaOH–modified titanium with aqueous solutions containing different types (aluminum, calcium, chromium, copper, zinc, and silver) and concentrations (0.01, 0.1, and 1 M) of metal ions. As a result, we found that formation of anatase and the chemical states of the metals incorporated into titanium control the apatite-forming ability. Further, the chemical states of the metals can be interpreted in terms of the ionization tendency. These findings would aid future design of metal-doped bioactive titanium for orthopedic or dental implants.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Publication statusPublished - 2018 Oct 20


  • Apatite-forming ability
  • Bioactive titanium
  • Simulated body fluid
  • Surface modification

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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